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How do biologic treatments work?

Biologic treatments stimulate natural tissue healing, working to enhance the body’s own repair process.

At the initial injury, the rupture of the tissue causes fluid to be released from the injured cells surrounding blood vessels. The body responds by sending new blood vessels and cells, which at first specialize in removing the damaged tissue and later stimulate new collagen formation to repair and replace the damaged tissue. Over time, other signals, chemicals and cells induce a maturation process to turn the immature healing tissue into mature strong replacement tissue.

Biologic treatments can augment and accelerate this process. The physician can help your body respond faster to the injury by providing a range of treatments. These can include a massage stimulating the receptors on cells to release healing factors, an injection of growth factors, or the surgical implantation of collagen scaffolds. Surgeons can also use human allograft donor tissue to entirely replace damaged tissue, and can even use animal device tissues called xenografts. During the healing process, additional treatments can speed up the maturation of the healing tissues and induce a stronger repair than might otherwise occur.

A wide range of biologic therapies are available today with more arriving each month

Avoid-a-total-knee-replacement-meniscus-transplant-arthritis-repair-stem-cell-paste-graft
We like to do everything possible to rebuild the knee joint with biologic tissues rather than artificial materials to help delay the time in which an artificial joint replacement is necessary.
The Great Stem Cell Divide
Stem cell therapies are sprouting like weeds. This is a good thing. The medical community is rushing into the biologic sciences, opening up the field of stimulating tissues to heal—rather than suppressing them with steroids, anti-inflammatories, or joint replacement surgeries. Here is my take on where the field is now and where it is going.
Standardized care is not always the best care. What we really need is an agile medical system that values innovation.
July 14th, 2015
In light of Wes Matthews and other NBA athletes suffering Achilles ruptures, Dr. Stone speaks to Mavs Moneyball, a...
April 27th, 2016
Dr Stone talking about Steph Curry's injury and the Warrior's season.
December 11th, 2014
"A few select orthopedic surgeons and researchers around the country are pioneering alternate cartilage...

Stone, K.R., A.W. Walgenbach, A. Freyer, T.J. Turek, and D.P. Speer. 2006.

Stone, K.R., A.W. Walgenbach, T.J. Turek, A. Freyer, and M.D. Hill. 2006.

A new treatment to replace the entire cartilage surface